TRANSITIONAL CELL CARCINOMA OF THE RENAL COLLECTING TUBULES (»NAL UROTHELIOMA«)

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Abstract
Carcinoma of the renal collecting tubules is presented for the 1st time in the literature by a systematic description of 18 renal specimens from cases with or without pelvis carcinoma. The study revealed a surprisingly high incidence of carcinoma in the collecting tubules in association with carcinoma of the pelvis (20%), but as a primary tumor, independent of the pelvic growth. In cases of invasive extension, it is also possible to distinguish between the 2 localizations of carcinoma by histological criteria. The finding of papillary structure, umbrella cells with keratohyaline or parakeratosis demonstrates that a carcinoma originating in the urothelium of the collecting tubules (renal urothelioma) corresponding entirely to carcinomas of the urinary tract was being studied. In a modification of the WHO histological grading of urinary tract tumors, the frequency of grades, I, II and III is stated for urothelioma and pelvis carcinomas. Perusal of the 18 case records did not divulge conclusive data as to whether smoking or the use/abuse of analgesics were operative as carcinogenic factors.