Copper(II) Chloride Mediated Racemization-Free Hydrolysis of α-Alkylated Ketone Samp-Hydrazones
- 1 January 1999
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 29 (1) , 27-33
- https://doi.org/10.1080/00397919908085731
Abstract
Treatment of ketone SAMP-hydrazones la-k with an aqueous copper(II) chloride solution yields the corresponding ketones 2a-k in 52-94% yield and with high enantiomeric purities (ee = 89-99%). The cleavage conditions do not affect functionalities sensitive to oxidation and strong acids. The alkylation/cleavage protocol can be carried out in ‘one-pot’.Keywords
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