Stereoselective binding of propranolol enantiomers to human alpha 1‐ acid glycoprotein and human plasma.
Open Access
- 1 August 1984
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 18 (2) , 244-246
- https://doi.org/10.1111/j.1365-2125.1984.tb02462.x
Abstract
The binding of propranolol enantiomers to human albumin (ALB), alpha 1- acid glycoprotein (alpha 1-AGP) and plasma was studied. (-) propranolol is more bound than (+)propranolol to alpha 1-AGP (P less than 0.001) and to plasma (P less than 0.05). In solutions containing ALB at a constant concentration (580 mumol/l) and alpha 1-AGP at increasing concentrations, the binding of both isomers increases but the stereo selectivity is evident throughout the alpha 1-AGP concentration range examined (25-100 mumol/l).Keywords
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