Cross‐reacting IgE antibodies recognizing latex allergens, including Hev b 1, as well as papain
- 1 July 1995
- Vol. 50 (7) , 604-609
- https://doi.org/10.1111/j.1398-9995.1995.tb01208.x
Abstract
The cross-reactivity of IgE antibodies recognizing epitopes of latex allergens and papain was studied in sera of 36 latex-exposed subjects and 22 papain workers. Eight out of 24 latex-sensitized persons also showed a positive reaction to papain in the CAP assay (mostly of low or moderate degree). On the other hand, six out of the 12 sensitized papain workers also revealed IgE binding to latex allergen(s). Reciprocal inhibition experiments confirmed that groups monosensitized to one of the two allergens can be separated from a group showing partial or nearly complete immunologic cross-reactivity. Papain inhibited IgE binding by 20-33% in these subjects, whereas IgE binding to papain was strongly blocked in most cases. Comparison between the primary sequences of Hev b 1, a major latex allergen, and papain suggests that the cross-reactivity may be due to several identical trimers and tetramers.Keywords
This publication has 11 references indexed in Scilit:
- Allergy to latex and papainJournal of Allergy and Clinical Immunology, 1995
- Latex allergyJournal of Allergy and Clinical Immunology, 1994
- One of the Rubber Latex Allergens Has Lysozyme ActivityInternational Archives of Allergy and Immunology, 1994
- The rubber elongation factor of rubber trees () is the major allergen in latexJournal of Allergy and Clinical Immunology, 1993
- Task Force on allergic reactions to latexJournal of Allergy and Clinical Immunology, 1993
- Latex antigensJournal of Allergy and Clinical Immunology, 1992
- Latex-specific proteins causing immediate-type cutaneous, nasal, bronchial, and systemic reactionsJournal of Allergy and Clinical Immunology, 1992
- Latex allergy in patient with allergy to fruitThe Lancet, 1992
- Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty‐three papain workers: Evidence for strong immunogenic potency and clinically relevant ‘proteolytic effects of airborne papain’Clinical and Experimental Allergy, 1982
- Studies on the specificity of human IgE‐antibodies to the plant proteases papain and bromelainClinical and Experimental Allergy, 1979