Two Complimentary Methods for the Synthesis of the Terminal N-Alkenyl-N-methylformamide Group Found in Cytotoxic Marine Macrolides
- 1 March 1996
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1996 (03) , 209-211
- https://doi.org/10.1055/s-1996-5383
Abstract
Two complimentary methods for the synthesis of trans-N-alkenyl-N-methylformamides from aldehydes are described. Method A involves condensation with MeNHCHO using P2O5, while Method B employs a Wittig reaction with 5 followed by I2-catalysed alkene isomerisation.Keywords
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