Lidocaine treatment of neonatal convulsions, a therapeutic dilemma
- 1 January 1989
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 36 (6) , 583-586
- https://doi.org/10.1007/bf00637740
Abstract
Three infants with neonatal convulsions were given lidocaine infusions for three days, three weeks and three months, respectively, and the plasma concentrations of lidocaine and its metabolites were analyzed by HPLC. After a prolonged infusion there was considerable accumulation of the metabolites. This may account for the difficulty of stopping the infusion without relapse of the seizures.Keywords
This publication has 14 references indexed in Scilit:
- Age-dependent lidocaine disposition in patients with acute myocardial infarctionClinical Pharmacology & Therapeutics, 1985
- Protein binding and disposition of lignocaine in the elderlyEuropean Journal of Clinical Pharmacology, 1985
- Maternal, fetal, and neonatal lidocaine levels following local perineal infiltrationAmerican Journal of Obstetrics and Gynecology, 1984
- Plasma levels, protein binding, and elimination data of lidocaine and active metabolites in cardiac patients of various agesClinical Pharmacology & Therapeutics, 1983
- Lidocaine Toxicity from Topical Mucosal ApplicationClinical Pediatrics, 1983
- Prolonged seizures associated with the use of viscous lidocaineThe Journal of Pediatrics, 1982
- Influence of long-term infusions on lidocaine kineticsClinical Pharmacology & Therapeutics, 1982
- Maternal, fetal, and neonatal metabolism of lidocaineClinical Pharmacology & Therapeutics, 1979
- The pharmacokinetics and metabolism of the anilide local anaesthetics in neonatesEuropean Journal of Clinical Pharmacology, 1978
- Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidideClinical Pharmacology & Therapeutics, 1975