Fetuin-B, a second member of the fetuin family in mammals.
- 1 September 2000
- journal article
- Vol. 350, 589-97
Abstract
A set of orthologous plasma proteins found in human, sheep, pig, cow and rodents, now collectively designated fetuin-A, constitutes the fetuin family. Fetuin-A has been identified as a major protein during fetal life and is also involved in important functions such as inhibition of the insulin receptor tyrosine kinase activity, protease inhibitory activities and development-associated regulation of calcium metabolism and osteogenesis. Furthermore, fetuin-A is a key partner in the recovery phase of an acute inflammatory response. We now describe a second protein of the fetuin family, called fetuin-B, which is found at least in human and rodents. On grounds of domain homology, overall conservation of cysteine residues and chromosomal assignments of the corresponding genes in these species, fetuin-B is unambiguously a paralogue of fetuin-A. Yet, fetuin-A and fetuin-B exhibit significant differences at the amino acid sequence level, notably including variations with respect to the archetypal fetuin-specific signature. Differences and similarities in terms of gene regulation were also observed. Indeed, studies performed during development in rat and mouse showed for the first time high expression of a member of the fetuin family in adulthood, as shown with the fetuin-B mRNA in rat. However, like its fetuin-A counterpart, the fetuin-B mRNA level is down-regulated during the acute phase of experimentally induced inflammation in rat.This publication has 46 references indexed in Scilit:
- The H4P Heavy Chain of Inter-α-inhibitor Family Largely Differs in the Structure and Synthesis of Its Prolin-Rich Region from Rat to HumanBiochemical and Biophysical Research Communications, 1998
- Effect of Phosphorylated Rat Fetuin on the Growth of Hepatocytes in Primary Culture in the Presence of Human Hepatocyte‐Growth FactorEuropean Journal of Biochemistry, 1997
- Friends and relations of the cystatin superfamily—new members and their evolutionProtein Science, 1997
- Cystatin-like domain of mouse countertrypin, a member of mammalian fetuin family, is responsible for the inhibition of trypsin. Evidence from site-directed mutagenesisIUBMB Life, 1996
- Cystatin C (CST3), the Candidate Gene for Hereditary Cystatin C Amyloid Angiopathy (HCCAA), and Other Members of the Cystatin Gene Family Are Clustered on Chromosome 20p11.2Genomics, 1993
- Primary structure of the rat gene encoding an inhibitor of the insulin receptor tyrosine kinaseGene, 1991
- Chromosomal assignments of 23 biochemical loci of the rat by using rat × mouse somatic cell hybridsCytogenetic and Genome Research, 1991
- α2-HS-glycoprotein: Expression in chondrocytes and augmentation of alkaline phosphatase and phospholipase A2 activityBone, 1991
- Inter-α-trypsin inhibitor: emergence of a family within the Kunitz-type protease inhibitor superfamilyTrends in Biochemical Sciences, 1990
- Cystatin domains in alpha‐2‐HS‐glycoprotein and fetuinFEBS Letters, 1988