Changes in specific airways conductance and forced expiratory volume in one second after a bronchodilator in normal subjects and patients with airways obstruction
Open Access
- 1 September 1974
- Vol. 29 (5) , 574-577
- https://doi.org/10.1136/thx.29.5.574
Abstract
Skinner, C. and Palmer, K.N.V. (1974).Thorax, 29, 574-577. Changes in specific airways conductance and forced expiratory volume in one second after a bronchodilator in normal subjects and patients with airways obstruction. Specific conductance (SGaw) and the forced expiratory volume in one second (FEV1) were measured in 10 normal, 10 asthmatic, and 10 obstructive bronchitic subjects before and after aerosol salbutamol. Mean SGaw increased by 37% in normals, by 109% in asthmatics, and by 38% in obstructive bronchitics. Mean FEV1 increased by 2% in normals, by 32% in asthmatics, and by 12% in obstructive bronchitics. SGaw appears to be a more sensitive indicator than FEV1 of changes in airways calibre following a bronchodilator drug in normal subjects, but FEV1 is as good an indicator of these changes as SGaw in patients with airways obstruction.Keywords
This publication has 8 references indexed in Scilit:
- Reversibility of Airways Obstruction in Chronic BronchitisClinical Science, 1972
- Mechanical consequences of airway smooth muscle relaxation.Journal of Applied Physiology, 1971
- The assessment of airflow obstructionRespiratory Medicine, 1971
- Acute effects of inhaled isoproterenol on the mechanical characteristics of the lungs in normal manJournal of Clinical Investigation, 1970
- Airways flow resistance as a measure of the efficacy of inhalants in clinical drug trials.1969
- Factors affecting airways conductance: a study of 752 working men.Journal of Applied Physiology, 1968
- Airway resistance as an index of effectiveness of bronchodilating drugsJournal of Allergy, 1966
- Evaluation of Methods Used in Detecting Changes of Airway Resistance in Man1,2,3American Review of Respiratory Disease, 1963