Excretion of sulfobromophthalein in rats with iodomethane-induced depletion of hepatic glutathione

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Abstract
Male urethane-anesthetized Wistar rats with biliary fistulas were infused for 60 min i.v. with sulfobromophthalein (BSP) or BSP-glutathione conjugate (BSP-GSH) at 594 nmol/100 g/min. Thirty minutes prior to the start of the infusion, 20 mg/kg iodomethane, dissolved in olive oil, was given into the duodenum. The control received oil only. At the start of the infusion the hepatic concentration of GSH was 0.96±0.23 mg/g liver in the iodomethanetreated animals versus 1.93±0.13 mg/g liver in the control (Pm) was double that observed with infusion of unconjugated BSP in control animals. There is indirect evidence that BSP and BSP-GSH might have different excretion pathways.