Prompt Confirmation of Rocky Mountain Spotted Fever: Identification of Rickettsiae in Skin Tissues

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Abstract
Rickettsia rickettsii were identifiable by the immunofluorescence technique in skin specimens obtained by biopsy on days 4 and 8 of illness from patients with Rocky Mountain spotted fever. The immunofluorescence technique is regarded as a practical means of confirming the diagnosis during the early stages of illness before positive serologic reactions can be obtained.