Lung Lipase Levels in Normal Rats and Rats With Experimentally Produced Fat Embolism.

Publisher Website
Google Scholar
Abstract
The gross and histological changes in the lungs of rats injected with triolein were similar to those seen in the lungs of patients dying with fat embolism. An elevation of the serum lipase activity in patients with fractures was diagnostic of pulmonary fat embolism. The result of this experiment indicated that there was an increase in the amount of lipase activity in the lung in experimental fat embolism in rats, and emphasized the role of enzymatic breakdown in the removal of embolic fat from the lung. It also suggested that the source of the excess lipase in the serum may be the lung.