PROTOFIBRILS, PORES, FIBRILS, AND NEURODEGENERATION: Separating the Responsible Protein Aggregates from The Innocent Bystanders
Top Cited Papers
- 1 March 2003
- journal article
- review article
- Published by Annual Reviews in Annual Review of Neuroscience
- Vol. 26 (1) , 267-298
- https://doi.org/10.1146/annurev.neuro.26.010302.081142
Abstract
▪ Abstract Many neurodegenerative diseases, including Alzheimer's and Parkinson's and the transmissible spongiform encephalopathies (prion diseases), are characterized at autopsy by neuronal loss a...Keywords
This publication has 199 references indexed in Scilit:
- Presenilins are not required for Aβ42 production in the early secretory pathwayNature Neuroscience, 2002
- Annular α-Synuclein Protofibrils Are Produced When Spherical Protofibrils Are Incubated in Solution or Bound to Brain-Derived MembranesBiochemistry, 2002
- Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseasesNature, 2002
- Binding of prion protein to lipid membranes and implications for prion conversionJournal of Molecular Biology, 2002
- Protofibrils, the unifying toxic molecule of neurodegenerative disorders?Nature Neuroscience, 2001
- The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formationNature Neuroscience, 2001
- Vesicle Permeabilization by Protofibrillar α-Synuclein: Implications for the Pathogenesis and Treatment of Parkinson's DiseaseBiochemistry, 2001
- A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic miceJournal of Molecular Biology, 2000
- Cytoprotective effect of NMDA receptor antagonists on prion protein (PrionSc)-induced toxicity in rat cortical cell culturesEuropean Journal of Pharmacology: Molecular Pharmacology, 1993
- Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisNature, 1993