IMMUNOGENETIC FACTORS IN HPV‐ASSOCIATED CERVICAL CANCER: INFLUENCE ON DISEASE PROGRESSION
- 1 August 1996
- journal article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 23 (4) , 275-284
- https://doi.org/10.1111/j.1744-313x.1996.tb00123.x
Abstract
No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB 1*1501/DQB 1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.Keywords
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