Increase of β-endorphin in cerebrospinal fluid after removal of ACTH-secreting pituitary adenomas
- 1 August 1981
- journal article
- research article
- Published by Wolters Kluwer Health in Pain
- Vol. 11 (1) , 127-132
- https://doi.org/10.1016/0304-3959(81)90146-9
Abstract
.beta.-Endorphin and met-enkephalin in CSF were measured before and after removal of an ACTH-secreting adenoma in Cushing''s disease by a sensitive radioimmunoassay and a radio-receptor assay, respectively. After tumor resection the level of ACTH in plasma markedly decreased from 82.6 .+-. 22.7 pg/ml to 16.7 .+-. 4.1 pg/ml (mean .+-. SE, n = 4). The level of .beta.-endorphin in CSF significantly increased from 32.0 .+-. 4.5 pg/ml to 61.8 .+-. 10.7 pg/ml (P < 0.05) after tumor resection while the level of metenkephalin in CSF remained unaltered. Hypophysectomy may induce an increase of .beta.-endorphin in CSF.This publication has 22 references indexed in Scilit:
- Radioreceptor assay of methionine-enkephalin-like substance in human cerebrospinal fluidPain, 1980
- ACUPUNCTURE IN HEROIN ADDICTS: CHANGES IN MET-ENKEPHALIN AND $beta;-ENDORPHIN IN BLOOD AND CEREBROSPINAL FLUIDThe Lancet, 1979
- Stimulation of Human Periaqueductal Gray for Pain Relief Increases Immunoreactive β-endorphin in Ventricular FluidScience, 1979
- Naloxone effects on a nociceptive response of hypophysectomized and adrenalectomized miceLife Sciences, 1978
- Determination of methionine enkephalin in discrete regions of rat brainBrain Research, 1977
- β-Endorphin and Adrenocorticotropin Are Selected Concomitantly by the Pituitary GlandScience, 1977
- Alcohol-Induced Adenolysis of the Pituitary GlandAnesthesia & Analgesia, 1977
- C fragment of lipotropin has a high affinity for brain opiate receptorsNature, 1976
- Identification of two related pentapeptides from the brain with potent opiate agonist activityNature, 1975
- Transsphenoidal hypophysectomyJournal of Neurosurgery, 1971