Age related changes in the inhibitory effect of clonidine on high K+-evoked noradrenaline release from brain slices of rats.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 11 (7) , 483-485
- https://doi.org/10.1248/bpb1978.11.483
Abstract
The effects of clonidine on a high K+-induced release of noradrenaline (NA) were studied in 70-d- and 2-year-old rats. Treatment with 0.1 and 1.0 .mu.M clonidine significantly (p < 0.01) inhibited 20 mM KCl-evoked L-[3H]NA release from cerebral cortical slices in 70-d-old rats. The amounts of high K+-evoked L-[3H]NA release were markedly decreased at 2 years, compared to that at 70 d. In addition, the inhibitory effects of clonidine on high K+-evoked L-[3H]NA release were no longer observed in 2-year-old animals. These results suggested that presynaptic functions, including the modulation of NA release by .alpha.2-adrenoceptors, could become low in the brains of the 2-year-old rats.This publication has 4 references indexed in Scilit:
- α2-adrenoceptor-GTP binding regulatory protein-adenylate cyclase system in cerebral cortical membranes of adult and senescent ratsBrain Research, 1986
- In vivo and in vitro studies on the regulation of cholinergic neurotransmission in striatum, hippocampus and cortex of aged ratsBrain Research, 1986
- Ontogeny of Influence of Clonidine on High Potassium-Induced Release of Noradrenaline and Specific [3H] Clonidine Binding in the Rat Brain CortexDevelopmental Neuroscience, 1982
- [3H]Dopamine accumulation and release from striatal slices in young, mature and senescent ratsBrain Research, 1981