Aminoethylprolyl Peptide Nucleic Acids (aepPNA): Chiral PNA Analogues That Form Highly Stable DNA:aepPNA2 Triplexes
- 15 October 1999
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 1 (10) , 1513-1516
- https://doi.org/10.1021/ol990835i
Abstract
The replacement of the glycyl component in the peptide nucleic acid (PNA) backbone by a prolyl unit bearing a nucleobase leads to the aminoethylprolyl (aep) PNAs, which are chiral and cationic. The homooligomeric aepPNA binds to complementary DNA sequences with high affinity and sequence specificity, forming highly stable triplexes.Keywords
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