Bacteria‐induced histamine release from human bronchoalveolar cells and blood leukocytes

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Abstract
Histamine release induced by Staphylococcus aureus was examined in cells obtained by bronchoalveolar lavage (BAL) in non‐topic individuals. Approximately half of the individuals responded with mediatior release to the bacterium, and the release was found to be time‐ and concentration dependent. No difference was found between the patients obtained by who responded and those who did not respond in regard to age, sex, smoker/nonsmoker % recovery of BAL‐fluid, total cell count, differential cell counts, histamine content per mast cell, or diagnoses. Also stimulation of the BAL‐cells with the calcium‐ionophore A23187 resulted in histamine release, S. aureus‐induced histamine release from basophils was examined in leukocyte suspensions obtained from the same individuals, and in all experiments release was found. The dose‐response curves were similar to those obtained with BAL cells‐ The bacteria‐induced mediator release from superficially lying cells in the airways epithelium might be of importance for the precipitation or exacerbation of bronchial asthma in respiratory tract infections.