On the use of tritium-labelled albumin for studies of intestinal absorption
Open Access
- 1 August 1964
- Vol. 5 (4) , 346-352
- https://doi.org/10.1136/gut.5.4.346
Abstract
Human serum albumin has been successfully labelled with tritium. It is considerably denatured in the process and has a shorter half life when given intravenously than 131I-labelled albumin. Nevertheless it is satisfactory for absorption studies, although not for turnover observations. These studies on absorption in control subjects and in patients with intestinal malabsorption indicate that the excreted radioactivity may have been derived from endogenous sources rather than from the results of malabsorption alone.Keywords
This publication has 8 references indexed in Scilit:
- Methodological aspects of gel filtration with special reference to desalting operationsJournal of Chromatography A, 1961
- Absorption and Elimination of 15N After Administration of Isotopically Labelled Yeast Protein and Yeast Protein Hydrolysate to Adult Patients with Coeliac DiseaseBMJ, 1960
- The Assay of Tritium in Biological Material by Wet Oxidation with Perchloric Acid followed by Liquid Scintillation CountingPhysics in Medicine & Biology, 1960
- THE RATES AND SITES OF ABSORPTION OF I-131-LABELLED ALBUMIN AND SODIUM I-131 IN THE RAT1960
- Studies of Intestinal Digestion and Absorption in the Human1Journal of Clinical Investigation, 1957
- Use of I131-Labeled Protein in the Diagnosis of Pancreatic InsufficiencyNew England Journal of Medicine, 1952
- USE OF I131-LABELED PROTEIN IN THE STUDY OF PROTEIN DIGESTION AND ABSORPTION IN CHILDREN WITH AND WITHOUT CYSTIC FIBROSIS OF THE PANCREASPediatrics, 1952
- COMPLETE BALANCE STUDIES OF NITROGEN, SULPHUR, PHOSPHORUS, CALCIUM, AND MAGNESIUM IN INTESTINAL INFANTILISMThe Journal of Experimental Medicine, 1912