Zoster Meningoencephalitis In a Steroid-Treated Patient

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Abstract
THE EARLY enthusiastic reports concerning the treatment of herpes zoster with corticosteroids1 have been followed by a number of publications. Several have shown that herpes zoster may develop during steroid treatment2-5 and in some cases the course of the disease was severe,4 with the development of gangrene5 and generalized herpes zoster. We have reported on an outbreak of a "house epidemic" of herpes zoster among corticosteroid-treated patients.8 In the steroid-treated patient to be described below, gangrenous herpes zoster developed, followed by a recurrence, generalization of the disease, and meningoencephalitis. We believe that the case is unique and therefore merits publication. Report of Case A female nurse, 50 years of age, was admitted July 4, 1960, with generalized herpes zoster. In childhood she had suffered from scarlet fever, morbilli, and varicella. Since the age of 40 years she had been treated with insulin for

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