Localization of Radioactivity in the Urinary Bladder and the Regional Lymph Nodes

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Abstract
In order to obtain basic information on radioactivity in the urinary bladder and regional lymph nodes as a guide for treatment of malignancies colloidal Au198 was injected intramurally into the urinary bladder of 12 dogs. Assay and histologic studies were made on dogs sacrificed at various time intervals ranging from 5 to 15 days. Concentrations of radioactivity were found to be consistently high at the site of injection as well as in the trigone of the urinary bladder and in the regional lymph nodes. Radiogold produced necrosis of the urinary bladder wall at the site of injection. Minor changes were noted in the regional lymph nodes. These results suggest the possibility of a clinical trial in patients with inoperable bladder carcinoma. Palliation might be afforded these patients if a sufficiently large amount of isotope were utilized creating an effective radiation dose.

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