Biotin Deficiency in Suckling Pigs

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Abstract
In suckling pigs started on experiment when the pigs were 48 hours old, biotin deficiency was apparently associated with ulceration of the skin, transverse cracking of the soles and top of the hoof, inflammation of the mucous membranes of the mouth, dermatitis, and alopecia. The urinary excretion of biotin failed to show the expected decrease and was not materially affected by the feeding of sulfathalidine. This may indicate that sulfathalidine does not inhibit the organisms responsible for intestinal synthesis of biotin in the suckling pig, or perhaps that some synthesis of biotin occurs in the tissues.

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