Focal Lipid Lesions in Blood Vessels due to Erythrocytes and Platelets

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Abstract
Experiments on goats and rabbits living on a normal diet demonstrated that the lipid associated with organizing thrombi became concentrated in fibrosed focal lesions of blood vessels. The lipid that appeared during organization of lysed erythrocytes underwent changes similar to those of lipid in thrombi. From this it was concluded that what red cells there were in the thrombi contributed to the total lipid present. These observations are pertinent to the pathogenesis of atherosclerosis, because they help to explain the thrombosis characteristically associated with this disease, and how lipid can be delivered to restricted regions of the arterial intima.