Effect of Tetracycline on the Phagocytic Function of Human Leukocytes

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Abstract
The effect of tetracyclines on phagocytosis by human neutrophils was studied. Human leukocytes incubated with tetracycline hydrochloride or doxycycline in vitro showed a decreased capacity to phagocytize yeast and bacteria. Furthermore, leukocytes harvested from healthy volunteers after ingestion of tetracycline also demonstrated decreased phagocytic capacity for yeast.