THE EFFECTS OF OESTROGENS ON BLUING LESIONS BY BRADYKININ AND HISTAMINE

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Abstract
The anti-bradykinin effect of oestrogens in the vascular permeability-increasing effect of bradykinin in the skin of rabbits was demonstrated by Miles and Miles's technique, i. e. by the so-called bluing lesions. Thus, The sizes of the bluing lesions induced by 0.01 μg of bradykinin were significantly reduced by conjugated oestrogens obtained from the urine of pregnant mares (Premarin) in a concentration of 0.2 μg, by synthetic oestrogens, namely hexoestrol in a concentration of 0.01 μg and oestriol dihemisuccinate (Styptanon) in a concentration of 2.0 μg, which were mixed in the same dose of bradykinin (P < 0.05), and the bradykinin-antagonistic effect of oestrogens was shown in each suitable concentrations. The larger and smaller doses of oestrogens reduced the sizes of the bluing lesions; however, the reduction was smaller than those obtained by their suitable concentrations and was not statistically significant. Conjugated oestrogens which were mixed in 0.1 μg and 0.001 μg of histamine failed to reduce the sizes of the bluing lesions induced by the same doses of histamine.

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