Exercise-induced increments in plasma levels of propranolol and noradrenaline.

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Abstract
Exercise‐induced changes in the plasma levels of propranolol and noradrenaline were determined in nine volunteers. Total plasma propranolol levels were increased during submaximal treadmill exercise, with exercise‐induced increments of 13 +/‐ 4% at 4 h after the last dose, 18 +/‐ 7% at 9 h and 41 +/‐ 5% at 16 h. Exercise‐induced increments in plasma propranolol were observed after single as well as repeated doses. During exercise, increments in plasma propranolol were correlated temporally with changes in plasma noradrenaline. Exercise‐ induced increments in plasma noradrenaline were greater during propranolol administration than during placebo periods. The changes in plasma propranolol concentration during exercise may reflect a redistribution of propranolol at its site(s) of action.