Differential regulation of GPI‐linked molecules on leukaemic promyelocytes treated in vitro with all‐trans retinoic acid
- 1 May 1996
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 93 (2) , 392-393
- https://doi.org/10.1046/j.1365-2141.1996.4861027.x
Abstract
It has been demonstrated that certain cell‐surface proteins are anchored to the cell membrane by a unique structure known as the glycosylphosphatidylinositol (GPI) anchor whose absence has been reported on blood cells from patients with paroxysmal nocturnal haemoglobinuria. We have investigated the expression of CD16/FcτR‐III and CD66b GPI‐linked molecules at the surface of blast cells from five acute promyelocytic leukaemia (APL) patients before and after in vitro stimulation with all‐trans retinoic acid (ATRA). We observed that whereas CD66b antigen exhibited a strong ATRA‐driven up‐regulation in all cases studied, CD16 expression was unaffected by the treatment with the drug.Keywords
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