CALPAIN INHIBITORS BLOCK TPA-DEPENDENT DOWN-REGULATION OF PROTEIN KINASE C
- 1 January 1990
- journal article
- research article
- Published by Biomedical Research Press in Biomedical Research
- Vol. 11 (5) , 313-317
- https://doi.org/10.2220/biomedres.11.313
Abstract
In vivo involvement of calpain in down-regulation of protein kinase C (PK-C) was studied in a neuroblastoma cell-line, BIM. Treatment of BIM cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) caused down-regulation of PK-C. Introduction of functional calpastatin peptide and inhibitors against calpain blocked TPA-dependent down-regulation of PK-C, while a control peptide and the other inhibitors had no effect. The results suggest in vivo involvement of calpain in down-regulation of PK-C during signal transduction.This publication has 17 references indexed in Scilit:
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