CELLULAR CHANGES PRODUCED BY EXTRACTS OF HUMAN ORGANS
Open Access
- 1 September 1946
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 1 (5) , 379-386
- https://doi.org/10.1182/blood.v1.5.379.379
Abstract
By the injection of lipoid extracts of organs (liver, spleen, and lymph nodes) of 5 patients with leukemia, 1 with Hodgkin's disease, and of 4 "control" cases (3 of heart disease and 1 of cerebral tumor) into 28 guinea-pigs, it was observed that: a. extracts from human myeloid leukemic organs produced "myeloid reactions" or infiltrations in guinea-pigs; b. extracts from lymphoid leukemic organs produced "lymphoid reactions"; c. extracts from organs involved with Hodgkin's disease produced "Hodgkin's reactions"; and d. extracts from "normal" organs produced slight lymphoid or monocytoid infiltrations.Keywords
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