THE EFFECT OF HYPOPHYSECTOMY IN RETARDING THE AGEING PROCESS OF THE LOOSE CONNECTIVE TISSUE OF THE RAT

Publisher Website
Google Scholar
Abstract
Hypophysectomy and subsequent growth hormone administration have been reported to have an effect on mucopolysaccharide metabolism. A technique is described by which comparative measurements are made of the ability of subcutaneous connective tissue to retain saline injected into it. This technique has been used in the examination of a group of hypophysectomized rats. Their tissue was found in this regard to have the character of that expected of normal rats about 100 days younger than those examined. This was the interval between the hypophysectomy and the examination of the tissues, and it is therefore suggested that hypophysectomy has an effect, specific or non-specific, that retards the ageing process of common connective tissue.