Hydrogen-bonded complexes of the ribodinucleoside monophosphates in aqueous solution. Proton magnetic resonance studies

Publisher Website
Google Scholar
Abstract
A PMR study of the chemical shifts of a series of ribodinucleoside monophosphates in neutral H2O solution was recorded in the 1-100 mM concentration range. The self-complementary dinucleoside monophosphates CpG and GpC and the complementary mixture GpU + ApC form intermolecular H-bonded complexes at low temperatures. The amino proton chemical shifts in the CpG and GpC spectra are consistent with the formation of a miniature double helical dimer in neutral aqueous solution at low temperatures (.apprx.2.degree. C). The complementary mixture of dinucleosides GpU + ApC formed much less stable complexes than either GpC or CpG, while UpA did not show any indication of the formation of intermolecular H-bonded complexes, consistent with the well-known observation that the stability of a double helix is proportional to the percent of G .cntdot. C base pairs present.

This publication has 0 references indexed in Scilit: