Delivery of Viral Vectors to Tumor Cells: Extracellular Transport, Systemic Distribution, and Strategies for Improvement
- 1 January 2006
- journal article
- review article
- Published by Springer Nature in Annals of Biomedical Engineering
- Vol. 34 (1) , 114-127
- https://doi.org/10.1007/s10439-005-9007-2
Abstract
It is a challenge to deliver therapeutic genes to tumor cells using viral vectors because (i) the size of these vectors are close to or larger than the space between fibers in extracellular matrix and (ii) viral proteins are potentially toxic in normal tissues. In general, gene delivery is hindered by various physiological barriers to virus transport from the site of injection to the nucleus of tumor cells and is limited by normal tissue tolerance of toxicity determined by local concentrations of transgene products and viral proteins. To illustrate the obstacles encountered in the delivery and yet limit the scope of discussion, this review focuses only on extracellular transport in solid tumors and distribution of viral vectors in normal organs after they are injected intravenously or intratumorally. This review also discusses current strategies for improving intratumoral transport and specificity of viral vectors.Keywords
This publication has 144 references indexed in Scilit:
- Cancer genes and the pathways they controlNature Medicine, 2004
- Progress and problems with the use of viral vectors for gene therapyNature Reviews Genetics, 2003
- Intratumoral Spread of Wild-Type Adenovirus Is Limited After Local Injection of Human Xenograft Tumors: Virus Persists and Spreads Systemically at Late Time PointsHuman Gene Therapy, 2003
- Immune Response to Poxvirus Infections in Various AnimalsCritical Reviews in Microbiology, 2002
- Factors Affecting Long-Term Expression of a Secreted Transgene Product after Intravenous Administration of a Retroviral VectorMolecular Therapy, 2001
- Catalytic Antibodies as Magic BulletsChemistry – A European Journal, 2000
- Amplification and Spread of Viruses in a Growing PlaqueJournal of Theoretical Biology, 1999
- Gene therapy for cancerEuropean Journal Of Cancer, 1999
- Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus disseminationGene Therapy, 1997
- Distribution of drugs following controlled delivery to the brain interstitiumJournal of Neuro-Oncology, 1995