Diabetic BioBreeding/Worcester (BB/Wor) rats need not be lymphopenic.
Open Access
- 1 May 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 136 (9) , 3254-3258
- https://doi.org/10.4049/jimmunol.136.9.3254
Abstract
The BB/Wor rat is an animal model of spontaneous autoimmune type I diabetes mellitus. Previous reports have emphasized the presence of lymphopenia in all diabetic and diabetes-prone BB rats. This manuscript reports the appearance of diabetes among three family lines of BB/Wor animals that were previously free of diabetes. Diabetic W-line rats are not lymphopenic and possess normal percentages of phenotypic T cell subsets. Hence the presence of lymphopenia is not obligatory for the occurrence of diabetes in BB/Wor rats.This publication has 20 references indexed in Scilit:
- Transfusions of Whole Blood Prevent Spontaneous Diabetes Mellitus in the BB/W RatScience, 1983
- Genetic analysis of the BB/W diabetic ratCanadian Journal of Genetics and Cytology, 1983
- CYCLOSPORIN PREVENTS DIABETES IN BB WISTAR RATSThe Lancet, 1983
- Spontaneous diabetes in BB rats: Evidence for a T cell dependent immune response defectDiabetologia, 1982
- Neonatal Thymectomy Prevents Spontaneous Diabetes Mellitus in the BB/W RatScience, 1982
- LYMPHOPENIA AND ABNORMAL LYMPHOCYTE SUBSETS IN THE “BB” RAT: RELATIONSHIP TO THE DIABETIC SYNDROMEEndocrinology, 1982
- DYNAMIC TIME COURSE STUDIES OF THE SPONTANEOUSLY DIABETIC BB WISTAR RAT .3. LIGHT-MICROSCOPIC AND ULTRASTRUCTURAL OBSERVATIONS OF PANCREATIC-ISLETS OF LANGERHANS1982
- Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex.The Journal of Experimental Medicine, 1981
- Spontaneous Diabetes in Rats: Destruction of Islets Is Prevented by Immunological ToleranceScience, 1981
- Two subsets of rat T lymphocytes defined with monoclonal antibodiesEuropean Journal of Immunology, 1980