APPLICATION OF THE ONE‐DIMENSIONAL ISING MODEL TO THE SECONDARY STRUCTURES IN GLOBULAR PROTEINS.
- 1 November 1976
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 8 (6) , 615-623
- https://doi.org/10.1111/j.1399-3011.1976.tb02542.x
Abstract
An attempt was made to predict the .beta.-regions in 16 globular proteins by applying the 1-dimensional Ising model theory of Lifson et Roig. The parameters were derived from the statistical data on globular proteins given by Chou et Fasman. Comparison of the results with data available from the X-ray crystallographic studies indicates a prediction accuracy which is comparable to those of other methods, especially in view of the limitations in this method for considering the other secondary structures. Not considering the long-range interactions in this and other methods based on short-range interactions would make these methods incomplete and incapable of being uniformly applicable to all proteins.This publication has 7 references indexed in Scilit:
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