A RECENT REVIEW1 concluded that magnetic resonance imaging (MRI) brain abnormalities are common in schizophrenia populations. Frequencies of regional changes, expressed as a percentage of studies reviewed, were 100% for volume loss in the superior temporal gyrus, 74% for medial temporal structures, 59% for prefrontal regions, 31% for the cerebellum, and 80% for ventricular enlargement.1 A contemporary meta-analysis2 also reported increased ventricular volume and decreases in medial temporal lobe structures and cerebral volume. Converging evidence from neuroimaging, neuropathological, and neurocognitive studies suggests that abnormalities in frontotemporal, frontostriatal,3-7 and frontothalamic-cerebellar8 pathways may explain many of the clinical manifestations of schizophrenia. It remains uncertain whether structural changes are reversible9 or progressive, at least in some patients,10 and whether different clinical and cognitive phenotypes are associated with distinctive brain abnormalities.