Effect of Di-Isopropyl Fluorophosphate (DFP) on the Action Potential of Muscle

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Abstract
The sartorius muscle of curarized frogs was excised and its action potentials, evoked by single electrical stimuli, were recorded by a cathode-ray oscillograph. The muscle when at rest was kept immersed in a Ringer soln. containing 0.1 mg./ml. of curarine. This soln. was then replaced by an identical soln. containing DFP, when the action potential of the muscle rapidly disappeared. With 2 mg. of DFP/ml. the potential was abolished in 8 mins., and with 1 mg./ml. the abolition took 20-30 mins. After washing with the cur-arine soln. the response reappeared. Acetylcholine may play a part in the muscle action potential.