EFFECTS OF ETHANOL ON THE DEVELOPING RAT .2. COORDINATION AS MEASURED BY THE TILTING-PLANE TEST

  • 1 January 1980
    • journal article
    • research article
    • Vol. 58  (3) , 164-168
Abstract
Ethanol, 27.1 mmol/kg body wt, was administered i.p. to rats in the weight classes 25, 50, 100, 150, 200 and 250 g. Controls were given saline, the total number of animals used being 120. Blood ethanol concentration and performance on the tilting-plane test was determined before and up to 6 h after administration. Total ethanol elimination was low in the smallest weight classes, increasing during adolescence. The 3 smallest weight classes showed no impairment of performance after ethanol, while the 150-250 g classes were significantly impaired during the time of maximum blood ethanol concentration.