The Toxicity of Chlorophacinone and Diphacinone to Deer Mice

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Abstract
Oat groat baits containing 0.00125, 0.0025, 0.005 and 0.01 and 0.02% concentrations of the anticoagulant rodenticides chlorophacinone (2-[p-chlorophenyl)-1-phenylacetyl]-1,3-indandione), or diphacinone (2-diphenylacetyl-1,3-indandione), were offered to 400 individually caged deer mice (Peromyscus maniculatus), with and without the availability of supplemental food, to determine their comparative effectiveness as control agents. No significant difference occurred in mortality with or without supplemental food. In the 2 day tests, only 0.02% chlorophacinone gave 100% mortality. Diphacinone produced 70-90% mortality in the 4 day tests with concentrations of .gtoreq. 0.0025% while chlorophacinone gave 100% mortality at all concentrations of .gtoreq. 0.0025%. Collective results of chlorophacinone (P < 0.01) were significantly more effective than the comparable concentrations of diphacinone on both the 2 and 4 day tests. The mortality difference between the 2 and 4 day results was significant (P < 0.01) for both compounds.

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