COMPONENTS OF INJURY (HAEMORRHAGE AND TISSUE ISCHAEMIA) AFFECTING CARDIOVASCULAR REFLEXES IN MAN AND RAT

Publisher Website
Google Scholar
Abstract
The effects of 2 components of tissue injury, namely fluid loss from the circulation and tissue ischemia, on cardiovascular reflex activity were studied. Moderate blood loss (10-20% blood volume) in the unanesthetized rat increased the slope of the regression line relating heart period to mean arterial blood pressure and usually displaced it to the left (i.e., towards a relative bradycardia). A blood donation of 500 ml (.apprx. 10% blood volume) increased the Valsalva ratio in conscious man without a change in resting pulse rate. A 15 min period of unilateral limb ischemia in man reduced the Valsalva ratio. The pattern of change in the pulse rate response to the Valsalva maneuver produced by limb ischemia closely resembles that found previously after limb injury in man. There was no evidence that the endogenous opioids were involved in the interaction between limb ischemia and cardiovascular reflex activity in man.

This publication has 0 references indexed in Scilit: