The roentgenologic features in 1 case of regional enteritis with involvement of the esophagus and in 10 cases of regional enteritis with gastric or duodenal involvement are described. Correct diagnosis was established prior to surgery or biopsy in 9 of the cases. In the other 2 cases, diagnosis was not established prior to surgery because the distal portion of the small bowel was normal roentgenologically in 1 case and was not examined in the other. The colon was not examined in either case. Difficulty in diagnosis may be encountered if the stomach, but not the duodenum, is involved with regional enteritis because the roentgenologic findings may resemble those of scirrhous carcinoma. Careful roentgenologic examination of the small bowel and colon will almost always reveal an area with characteristic changes of regional enteritis, and thus will account for the gastric or duodenal abnormalities.