Multiple Glomus Tumors

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Abstract
A man had widespread, slowly evolving vascular lesions since infancy suggestive of the blue rubber bleb nevus syndrome. His son had 2 painless lesions typical of multiple glomus tumors. Many of the man''s nodular lesions were painful. Postexcision recurrences were noted. Histologic studies of asymptomatic tumors from both cases showed irregular, dilated, vascular channels surrounded by narrow mantles of glomus cells, whereas a painful tumor had large foci or glomus cells with wider mantles around the flattened channels. EM showed the glomus cells to be modified smooth muscle cells. The anatomy and pathology of glomus tumors are reviewed. Differentiation from other syndromes of multiple hemangiomas, particularly the blue rubber bleb nevus syndrome is stressed. Multiple glomus tumors may probably be derived from simple cutaneous vessels and not the Sucquet-Hoyer canal of the normal cutaneous glomus body described by Masson.

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