A TYPICAL HEREDITARY SYNDROME

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Abstract
Turner1 has reported the very interesting history of two families in both of which "arthrodysplasia" associated with dystrophy of the nails has occurred as a dominant mendelian character through four generations. The author attempted to clarify the facts from a genetic point of view. Probably he was not familiar with the literature on the association of dystrophy of the nails with skeletal anomalies, since he suggested one pathologic hereditary factor for his first family in which all the affected members showed both anomalies. For the other family, in which several members presented only dystrophy of the nails, he postulated two different pathologic factors, one of which (the factor for arthrodysplasia) manifested itself only when the other factor was also present. Besides, the author thought there was a possibility that there existed a third factor, which, whenever it was present, inhibited the factor for arthrodysplasia, so that only the nail