EFFECT OF LEVAMISOLE ON CELL-MEDIATED-IMMUNITY AND SUPPRESSOR CELL-FUNCTION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (3) , 952-955
Abstract
The immunopotentiating drug, levamisole, augmented human lymphocyte responses to allogeneic cells and plant mitogens in vitro. The effect was critically dose dependent and, at high doses, suppression rather than augmentation of the immune response was observed. The hypothesis that augmentation of immune responses by the drug is due to the selective impairment of immunoregulatory suppressor activity was tested in a model using human splenic and thymic suppressor cells. The drug was capable of augmenting suppressor activity rather than abolishing it. Levamisole is a nonspecific stimulator of lymphocyte function, irrespective of the role played by these cells in the human response.

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