Macrophage Response to Experimental Implantation of Polypropylene Prostheses

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Abstract
We have assessed the macrophage response to polypropylene mesh (Marlex®) implanted into the abdominal wall of New Zealand white rabbits, using RAM-11 a monoclonal antibody specific for rabbit macrophages. The response diminishes during the course of the first 90 days after implantation, although the presence of other cell tpyes typical of foreign-body reactions increases. We have also confirmed the high degree of integration of the biomaterial into the wall achieved after 9 weeks. This has been determined using light and scanning electron microscopy. Likewise, we have observed the formation of numerous adhesions between the polypropylene mesh and the viscera of the abdominal cavity.

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