Simultaneous quantitative estimates of several isotopically labelled substances in the picogram range with selected ion monitoring
- 1 August 1979
- journal article
- research article
- Published by Wiley in Journal of Mass Spectrometry
- Vol. 6 (8) , 335-339
- https://doi.org/10.1002/bms.1200060805
Abstract
The use of a model developed by the authors for the simultaneous quantitative determination of several isotopically labelled substances of the same chemical structure is described in detail for a two substance system. A computational flow chart is included. An example using natural estradiol and 4‐[14C] labelled estradiol with manifold deuterated estradiol as an internal standard is presented. The basis of the model is discussed.Keywords
This publication has 12 references indexed in Scilit:
- Quantitative estimates for isotopic dilution analysis in mass spectrometryAnalytical and Bioanalytical Chemistry, 1979
- Monitoring of the oral contraceptive 17α-ethinyloestradiol-17β in human plasma by isotopic-dilution mass spectrometryAnalytical and Bioanalytical Chemistry, 1978
- Isotopic dilution mass spectrometry of oestriol and oestradiol-17β — an approach to definitive methodsAnalytical and Bioanalytical Chemistry, 1978
- Evidence for the lack of a carrier effect in the solvent extraction and determination of octopamine by gas chromatography mass spectrometryJournal of Mass Spectrometry, 1977
- A review of the statistical considerations involved in the treatment of isotope dilution calibration dataJournal of Mass Spectrometry, 1976
- Theoretical considerations in stable isotope dilution mass spectrometry for organic analysisAnalytical Chemistry, 1976
- The derivation and use of biosynthetic incorporation and dilution valuesPhytochemistry, 1975
- Incorporation and dilution values—Their calculation in mass spectrally assayed stable isotope labeling experimentsBioorganic Chemistry, 1974
- Determination of plasma testosterone by combined gas chromatography-mass spectrometryJournal of Chromatography A, 1974
- High-accuracy determination of calcium in blood serum by isotope dilution mass spectrometryAnalytical Chemistry, 1972