α2-Adrenoceptor Changes During Cerebral Ageing. The Effect of Ginkgo biloba Extract
- 1 January 1992
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 44 (1) , 24-27
- https://doi.org/10.1111/j.2042-7158.1992.tb14357.x
Abstract
[3H]Rauwolscine binding to α2-adrenoceptors in cerebral cortex and hippocampus membranes of young (4 months) and aged (24 months) Wistar rats has been investigated. In aged rats, Bmax values of [3H]rauwolscine binding were significantly reduced (25–32%) in the cerebral cortex and hippocampus, as compared with the number of α2-adrenoceptors found in young rats. Chronic treatment with Ginkgo biloba extract did not alter [3H]rauwolscine binding in the hippocampus of young rats, but significantly increased (28%) the [3H]rauwolscine binding density in aged rats. These data confirm the previously described age-related noradrenergic alteration and suggest that noradrenergic activity in aged rats is more susceptible to Ginkgo biloba extract treatment.Keywords
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