Effects of isoprenaline on coronary blood flow: its distribution and myocardial performance

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Abstract
Isoprenaline was intravenously infused into open chest anaesthetized dogs and myocardial contractile force, cardiac output, and coronary blood flow distribution were monitored. The inotropic response to isoprenaline could be sustained only when the normally homogeneous left ventricular flow distribution was maintained. Contractile force fell when subendocardial muscle became underperfused relative to subepicardial muscle and was improved when coronary perfusion pressure and relative subendocardial flow were increased. Changes in flow distribution could be predicted from the ratio of the diastolic pressure time index and the tension time index (DPTI:TTI).

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