Genetic variability in response to infection: malaria and after
Open Access
- 1 September 2002
- journal article
- review article
- Published by Springer Nature in Genes & Immunity
- Vol. 3 (6) , 331-337
- https://doi.org/10.1038/sj.gene.6363878
Abstract
Recent studies have shown that the relatively short period of exposure of human populations to malaria has left in its wake a wide range of genetic diversity. And there is growing evidence that other infectious agents have, or are, having the same effect. By integrating further studies of human populations with genetic analyses of susceptibility to murine malaria it should now be possible to determine some of the mechanisms involved in the variation of susceptibility to infectious disease, information which may have important practical implications for both the diagnosis and better management of these conditions.Keywords
This publication has 45 references indexed in Scilit:
- Genetics of susceptibitlity to human infectious diseaseNature Reviews Genetics, 2001
- Haemoglobin C protects against clinical Plasmodium falciparum malariaNature, 2001
- The Thalassaemia SyndromesPublished by Wiley ,2001
- α + -Thalassemia protects children against disease caused by other infections as well as malariaProceedings of the National Academy of Sciences, 1997
- Why are some genetic diseases common?Human Genetics, 1993
- Common West African HLA antigens are associated with protection from severe malariaNature, 1991
- Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.Proceedings of the National Academy of Sciences, 1986
- High frequencies of α-thalassaemia are the result of natural selection by malariaNature, 1986
- Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene clusterNature, 1982
- Nonrandom association of polymorphic restriction sites in the β-globin gene clusterProceedings of the National Academy of Sciences, 1982