Double Protection of the Heterocyclic Base of Xanthosine and 2′-Deoxyxanthosine
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 8 (2) , 159-178
- https://doi.org/10.1080/07328318908054165
Abstract
Reaction of O-protected xanthosines with p-nitrophenyl ethanol under Mitsunobu conditions yields the doubly alkylated O2,O6- and N1-,O2-derivatives. Deoxyxanthosine protected on both oxygens with a 2-(4-nitrophenyl)-ethyl group was synthesized starting from deoxyguanosine. Both protecting groups can be eliminated with DBU in pyridine.Keywords
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