Biosynthesis of uridine monophosphate inPlasmodium berghei
- 1 April 1980
- journal article
- research article
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 74 (2) , 109-114
- https://doi.org/10.1080/00034983.1980.11687320
Abstract
High activities of the enzymes orotate phosphoribosyltransferase and orotidylate decarboxylase, that convert orotic acid to uridine monophosphate, have been demonstrated in crude super-natants obtained from lysed Plasmodium berghei. The enzymes are inhibited in vitro by 5-azaorotate, 5-azauracil and 6-azauracil. Of these, 5-azaorotate was the most effective and could serve as the prototype of a potential antimalarial.This publication has 11 references indexed in Scilit:
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