Serotonin 5-HT 3 receptor antagonists prevent cisplatin-induced emesis in Cryptotis parva: a new experimental model of emesis
- 16 December 1998
- journal article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 105 (10-12) , 1143-1154
- https://doi.org/10.1007/s007020050118
Abstract
The aim of this manuscript is to introduce Cryptotis parva (the least shrew) as a new experimental emesis model. The chemotherapeutic agent, cisplatin, caused a dose-dependent increase in the number of animals exhibiting vomiting and retching behaviours with ED50 values of 6.43 ± 1 and 7.9 ± 1.2 mg/kg, respectively. The frequencies of these parameters were also dose-dependent. Intraperitoneal administration of 5-HT3 receptor antagonists (tropisetron or MDL 72222) prevented cisplatin-induced emesis and retching behaviours in the least shrew by a dose-dependent mechanism with respective ID50 values of 4.28 ± 2.8 and 2.05 ± 2 for emesis, and 2.71 ± 4.5 and 2.52 ± 2.59 for retching. Intraperitoneal injection of selective and nonselective 5-HT3 receptor agonists potently, and in a dose-dependent fashion, induced emesis in the least shrew with the following ED50 potency order: 2-methyl 5-HT ≈ 5-HT (p > 0.05) 3 receptors indirectly via release of 5-HT.Keywords
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